Nutrition Diagnostics - The Role of L- Glutathione

The Role of L- Glutathione

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How to pronounce L - Glutathione ( El Gluta Thigh Own)


Glutathione is an antioxidant designed to preserve the integrity of cells, and plays a key role in defending against viral infections. Viruses enter the body encased within a protein shell known as a 'capsid'. Before a virus can infect the body, it must first bind to a cell and activate its 'neuraminidase' enzyme, which injects the virus into the cell. The virus then multiplies within the cell - ultimately causing the cell to burst, at which point the virus escapes the cell and then infects the body. However, if the capsid does not bind to a cell, it can be naturally escorted out of the body by white blood cells - meaning no viral infection. One of the functions of glutathione is to ensure viruses do not escape this capsid and infect the body.

Note, Glutathione can be synthesized by the body naturally by obtaining 3  amino acids:

  1. Glutamic acid -BIO-Whey and meat
  2. Cysteine - BIO-Whey and meat
  3. Glycine - BIO-Whey and BIO-Vitamin C
  4. Selenium status - Formula 2 and iron status - Formula 3


Why Supplement with Glutathione


Immunity
Detox
Antioxidant

While holistic dentistry has become a franchise and most are removing their amalgam, it has seem to make some people emplacement as it is not longer the buzz word and unfortunately they underestimate the ravages effects of mercury. 

The storage molecule, metallothionein, the cell protecting molecule of glutathione, the circulating proteins that include apoE rich HDL, albumin, haemoglobin, selenoprotein are amongst the essential detoxification substances. Finally vitamin C supplies high energy electrons needed for these detox systems to suceed.

Mercury is the most persistent and pervasive of all of the environmental toxins, as well as the most toxic. The means by which mercury is eliminated is identical to detoxification strategies for all other toxins from the body.


Supply detox diagram.


Glutathione vs NAC vs L-Glutathione


lipospheric
liposomal
powder


L-Glutathione is a sulfur-containing tripeptide that is an important part of the body’s antioxidant defense system. Because of its antioxidant properties, glutathione neutralizes damaging free radicals and peroxide molecules, and recharges oxidized vitamin C so that the body may reuse it. Optimal amounts of L-glutathione are necessary for supporting the immune system and help the liver to detoxify chemicals. * Reduced L-glutathione is the most active form.

 

 

* These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.


Safety of Glutathione

https://www.tga.gov.au/sites/default/files/foi-189-1314-1.pdf

Australian Goverment
Department of Health
Therapeutics Goods Administration
ACCM 14th Advisory Commitee on Complementary Medicines
Ratified Minutes 2nd August 2013
TGA health safety regulation

Evaluation of glutathione Trade name Setria(r)-
endogenously produced antioxidant.
Doses 250 to 1000mg/day in capsule / powder.

present in the body and in food. It has been estimated in America a typical dietary intake is up to 150mg/day.
GSH containing products have been used in orphan drugs for the treatment of AIDS-associated cachexia, parkison's and diabetes.

1 safey issue TGA identified in a published human clinical sudy, reported lightening of skin colour following oral intake of GSH twice daily at 250mg for 4 weeks (2012).
High supplemental doses of GSH and its Genotoxic risk effects is unknown. Studies have not looked at GSH storage levels in kidney and liver. Studies have only looked at intestinal absorption instead of sublingual.

So there have not been any enthusism looking at high repeat dose in long term safety studies by the TGA.

Medico legally as there are complex variables in lactation and pregnancy everyone is siding with caution and passing the onus on to a health care practitioner for sale.

Another safety concern was for oral GSH intake to affect reproduction and foetal development. The only safety studies that were performed on toxicity were on animal models (mice and rabbits) not looking at foetal effects, dosing pre-mating and mating periods and route of administration was intravenous.

"However, the possibility that oral GSH results in significantly increased levels of GSH in the body is unlikely and hence the likelihood that GSH may have an effect on reproduction and development is low."

Studies have been held for only 4 weeks.

"The ACCM advises the TGA that given context of wide use and its endogenous nature (internally made), glutathione is generally considered safe for use in oral listed medicines. However, the committee had concerns regarding potential confounding effects with other agents and its effect on melanin production which should be mitigated by a suitable advisory statement and a daily dose limit of 500mg. "



https://www.metabolicmaintenance.com/Amino-Acids/L-Glutathione-Reduced/

What is L-Glutathione (Reduced)?

Glutathione is a sulfur-containing tripeptide made up of the amino acids cysteine, glycine, and glutamate. As the body’s “master antioxidant,'' glutathione neutralizes damaging free radicals and peroxide molecules and boosts the utilization and recycling of other antioxidants, namely vitamins C and E, alpha lipoic acid, and CoQ10. 

There are two forms of glutathione, reduced glutathione or L-glutathione, is the active form, and oxidized glutathione (GSSG), the inactive form. However, GSSG can be reactivated in the body by glutathione reductase to be used again. Optimal amounts of L-glutathione are necessary for supporting the immune system and help the liver to detoxify chemicals. 

Until recently, the bioavailability of orally supplemented L-glutathione was questioned. However, oral dosages of Setria® glutathione, specifically, have been shown to increase glutathione levels within the body stores of healthy adults [1].

 

How does L-Glutathione (Reduced) Work?

Glutathione is an antioxidant that plays an important role in cellular defense, nutrient metabolism, and regulation of cellular events (such as gene expression, DNA and protein synthesis, cell proliferation and apoptosis, signal transduction, cytokine production and immune response, and protein glutathionylation) throughout the body [2, 3]. Glutathione deficiency contributes to oxidative stress, which plays a key role in aging and the pathogenesis of many diseases [4]. 

Glutathione is found to be most concentrated, respectively, in the liver, spleen, kidney, lens, red, and white blood cells, which supports the fact that glutathione deficiency has been linked to a number of disease states in these tissues and cell types [4]. In specific relation to the immune system, glutathione deficiency is known to impair immune function [5]. Because serious glutathione depletion can occur under conditions of trauma and stress, maintenance of adequate glutathione levels may enhance immunocompetence and thus improve the ability of patients to recover from illness or physical stress [5].


Recommendations: Use as directed by a healthcare professional.

 

Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.

* These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.


Can GSH cause a detox reaction?


Gluthione does not pull toxis, instead it binds and emeliorates, as the absorption rate is limiting.



Bioceuticals: Not recommended for use by pregnant and lactating women (or words to that effect).


Glutathione can be made by the body being derived from food.
Glutathione is also naturally found in breast milk.

The TGA is more confidence is taking pharmaceutical risks with medications than they are with supplements. When there is limited research on particular supplements evem though vitamins and minerals can be found in food existing in different forms, a side of caution generally warranted.


Antioxidant/Reduce free radicals formed in the body
Helps reduce/decrease free radical damage to body cells
Maintain/support general health and wellbeing
Maintain/support immune system health
Maintain/support healthy immune system function Maintain/support (state vitamin/mineral/nutrient) levels in the body
Label statement: [Vitamins/minerals/nutrients/dietary supplements] can only be of assistance if dietary intake is inadequate OR [Vitamins/minerals/nutrients/dietary supplements] should not replace a balanced diet (or words to that effect).
If product is indicated for supplementation, Label statement: [Vitamins/minerals/nutrients/dietary supplements] can only be of assistance if dietary intake is inadequate OR [Vitamins/minerals/nutrients/dietary supplements] should not replace a balanced diet (or words to that effect).
Product presentation must only refer to detoxification in relation to natural body processes.


https://www.tga.gov.au/sites/default/files/foi-189-1314-1.pdf

"Another safety concern was the potential for oral GSH intake to affect reproduction and foetal development. The TGA noted the reproductive and developmental toxicity studies conducted with GSH in animal models (mice and rabbits) were limited in scope. Foremost, the studies were not adequately designed to investigate feotal effects, dosing did not encompass pre-mating and mating periods and the route of administration of GSH was intravenous. However, as discussed above, the possibility that oral GSH results in significantly increased levels of GSH in the body is unlikely and hence the likelihood that GSH may have an effect on reproduction and development is low.

The members noted that GSH is presented in foods and in normal human metabolism, which provides a context for safe use. 
ACCM advises the TGA that given the context of wide use and its endogenous nature, glutathione is generally considered safe for use in oral listed medicines. 


Safety in Pregnancy and Lactation

" I am unable to find information regarding whether I can take this while breastfeeding (I am exclusively breastfeeding a 3 month old). I am comfortable with the other supplements in the protocol but I wonder if you have information on safety of glutathione for lactation. "

Warnings

Not recommended for use by pregnant and lactating women (or words to that effect).
Vitamins can only be of assistance if the dietary vitamin intake is inadequate. OR Vitamin supplements should not replace a balanced diet. Adults only.


20493Ansar H., Mazloom Z., Kazemi F., Hejazi N. Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients. Saudi Med J 2011;32(6):584-588.

14546Capel ID, Jenner M, Williams DC, et al. The effect of prolonged oral contraceptive steroid use on erythrocyte glutathione peroxidase activity. J Steroid Biochem 1981;14:729-32. 

20493Ansar H., Mazloom Z., Kazemi F., Hejazi N. Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients. Saudi Med J 2011;32(6):584-588.
14546Capel ID, Jenner M, Williams DC, et al. The effect of prolonged oral contraceptive steroid use on erythrocyte glutathione peroxidase activity. J Steroid Biochem 1981;14:729-32.


L-Glutathione vs NAC

How to take

Disclaimers:

Consult with a health care professional otherwise, glutathione is not recommended in pregnancy and lactation.

Glutathione is generally not recommended that anything that can cause a detox reaction is not recommended. They said it can potentially pull toxins into the placenta and breast milk as it binds to heavy metals, noting there has not been alot of research so they are siding with caution.

I thought it does not pull it binds to ameliorate, due to absorption rate is limiting.
It is also naturally found in breast milk.

It's a tricky one as it is a supplement risk and there are other  variables like a mothers dental amalgams the Australian Dental Association promotes while the FDA is now concerned with.

https://www.ada.org.au/Dental-Professionals/Policies/Dental-Practice/6-18-Safety-of-Dental-Amalgam/ADAPolicies_6-18_SafetyofDentalAmalgam_V1.aspx

Dental amalgam should continue to be available for use as a dental restorative material. Dental clinics should practice good mercury hygiene.
Dental amalgam has been used as a dental restorative material for more than 150 years. It has proved to be a durable, safe and effective material which has been the subject of extensive research over this time. 

There is no evidence to support an association between the presence of amalgam restorations and chronic degenerative diseases, kidney disease, autoimmune disease, cognitive function, adverse pregnancy outcomes or any non-specific symptoms;

Further research into the possible adverse effects of dental amalgam is desirable; 

The National Health and Medical Research Council has attested to the value and safety of dental amalgam but has suggested that it would be prudent to reduce its use in special populations, including children, women in pregnancy and persons with existing kidney disease.

  1. DENTAL AMALGAM is a mixture of metals including silver, copper and tin with mercury forming a stable alloy.
    1. Dental amalgam should continue to be available as a dental restorative material.
    Dentists should minimize the use of dental amalgam in children, pregnant or breastfeeding women and in individuals with kidney disease.

Amended by ADA Federal Council, November 20, 2020

https://www.fda.gov/medical-devices/dental-devices/dental-amalgam-fillings

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